Journal of Bioequivalence & Bioavailability

Feddah H

Publications

• Research Article
  Bioequivalence of a Fixed Dose Combination of Desloratadine/Betamethasone Tablets (Oradus Beta) in Healthy Human Volunteers
  Author(s): Bustami R, Khasawneh S, Absi W, Feddah H, Menassa M, Daccache E, Taha MS and Kyriacos SBustami R, Khasawneh S, Absi W, Feddah H, Menassa M, Daccache E, Taha MS and Kyriacos S
  
  A fixed dose combination of desloratadine, a long-acting tricyclic antihistamine with selective peripheral histamine H1 receptor antagonistic activity, and betamethasone, a glucocorticoid, can potentially provide synergistic effect in the treatment of severe allergic conditions and improve clinical outcomes. Co-administration of an anti-allergy medication and a corticosteroid is extensively used in clinical practice, either as single drug tablets or as a fixed dose combination tablet. The current study was conducted to compare the pharmacokinetics of fixed combination tablets of desloratadine and betamethasone in 40 healthy human volunteers after a single oral dose in a randomized two-period, two-treatment, and two-sequence cross-over study. The study protocol was prepared in accordance to the requirements set in the EMA guidance for conducting bioequivale.. View More»
  DOI: 10.4172/jbb.1000301

  Abstract PDF