Journal of Bioequivalence & Bioavailability

Farzaneh Lotfi poor

Publications

• Research Article
  Pharmacokinetic Study of Two Macrolide Antibiotic Oral Suspensions Using an Optimized Bioassay Procedure
  Author(s): Parvin Zakeri-Milani, Saeed Ghanbarzadeh, Farzaneh Lotfi poor, Morteza Milani and Hadi ValizadehParvin Zakeri-Milani, Saeed Ghanbarzadeh, Farzaneh Lotfi poor, Morteza Milani and Hadi Valizadeh
  
  Purpose: Erythromycin (ERY) (CAS 114-07-8) is a macrolide antibacterial with a broad and essentially bacteriostatic action and Azithromycin (AZI) (CAS 83905-01-5) is a semi-synthetic, acid stable erythromycin derivative with an expanded spectrum of activity and improved tissue pharmacokinetic characteristics relative to ERY. The aim of the present study was to develop an optimized procedure for determination of macrolide antibiotics in human serum as well as to compare the bioequivalence of two commercial brands of Erythromycin and Azithromycin Suspensions in healthy Iranian volunteers. Methods: Two brands of erythromycin ethylsuccinate and azithromycin oral suspensions were used. An equivalent 400-mg ERY suspension and 500-mg AZI suspension were given orally to each subject in two separate studies as a single dose with 200 ml of water. ERY and AZI concentrations in serum were deter.. View More»
  DOI: 10.4172/jbb.1000041

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