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Farghali AA
Farghali AA
Beni-Suef
Egypt
Publications
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Research Article
pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles
Author(s): Khaled EA AbouAitah, Farghali AA, Anna Swiderska-Sroda, Witold Lojkowski, Abdel-Fattah M Razin and Khedr MHKhaled EA AbouAitah, Farghali AA, Anna Swiderska-Sroda, Witold Lojkowski, Abdel-Fattah M Razin and Khedr MH
Mesoporous silica materials are promising drug delivery systems, especially in case of poorly water-soluble drugs. Curcumin (Cur) has proven effective for several pharmacological activities including anti-inflammatory, antioxidant, antimicropeal, hepatoprotective, and anticancer activities. In the present work two types of mesoporous silica nanoparticles were evaluated as a Cur carrier for controlled release of this anticancer natural pro-drug: MCM-41 (Two Dimensional) and KCC-1 (Three Dimensional), both functionalized with aminopropyl groups. KCC-NH2 and MCM-NH2 contained a similar amount of Cur (24.5% and 23.9%, respectively). In vitro experiments have shown that both materials effectively release Cur and the cumulative release was enhanced for low acidity (pH=2.5). At low acidic pH (2.5), the KCC-1 sample released higher amount (up to 19%) of curcumin c.. View More»
DOI: 10.4172/2157-7439.1000351