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Fadeeva E
Fadeeva E
Germany
Publications
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Research Article
Enhanced Bioactivity of Titanium by Laser-generated Lotus-Topographies: Molecular Insights in Osteogenic Signaling Pathways of hASCs
Author(s): Fadeeva E, Deiwick A, Chichkov B and Sabrina Schlie-WolterFadeeva E, Deiwick A, Chichkov B and Sabrina Schlie-Wolter
Laser-generated lotus-topographies were shown to fulfill important requirements of demanded bioactivity: inhibition of biofilms and fibrotic capsule formation and enhanced regeneration. Here, we figure out how the demonstrated markerspecific improved osteogenic differentiation of human adipose-derived stem cells (hASCs) is accomplished. Comparing flat and lotus-structured titanium, the role of the osteogenic signaling pathways via extracellular-signal related kinase (ERK), c-Jun-N-terminal kinase (JNK), and p38 mitogen-activated protein kinases (MAPKs), and interplay with ERK/ p-ERK and bone morphogenic protein (BMP2)/p-Smad signaling are determined. To our knowledge, this interaction has not been analyzed before. Blocking of ERK and JNK suppresses osteogenic markers like alkaline phosphatase (ALP) activity and calcium mineralization independently from the surface. Their functionality re.. View More»
DOI: 10.4172/2157-7439.1000403