Journal of Bioequivalence & Bioavailability

F. V. Manvi

Publications

• Research Article
  Development and Characterization of Solid-Lipid Microparticles of Highly Insoluble Drug Sirolimus
  Author(s): Basavaraj K. Nanjwade, Didhija J. Patel, Kemy A. Parikh, Veerendra K. Nanjwade and F. V. ManviBasavaraj K. Nanjwade, Didhija J. Patel, Kemy A. Parikh, Veerendra K. Nanjwade and F. V. Manvi
  
  Solid lipid microparticles (SLMs) represent an alternative carrier system to traditional colloidal carrier such as emulsion, liposomes and polymeric micro and nanoparticles. The purpose of this research work was to develop and evaluate solid lipid microparticles of sirolimus for oral delivery. Sirolimus is an immunosupressive drug used to prevent transplant rejection and to treat auto immune diseases. It is a macrolide lactone produced by streptomyces hydroscopicus . It is extremely hydrophobic. Sirolimus solid lipid microparticles were prepared by hot homogenization technique. The matrix chiefly consisted of glyceryl monostearate and sodium taurocholate. The SLMs were studied for its particle size analysis, drug content, entrapment efficiency, in vitro release characteristics and also for stability analysis at different temperature and humidity conditions. Average particle size was f.. View More»
  DOI: 10.4172/jbb.1000050

  Abstract PDF