Journal of Clinical & Experimental Pharmacology

Engin Sahna

Publications

• Research Article
  Comparative Effectıveness of Novokinin, Perindopril and Losartan on Blood Pressure, Adma, Nadph Oxidase and Rho Kinase at Renal Tissue in L-Name and Salt Induced Hypertension
  Author(s): Emre Mutlu*,Necip Ilhan,Nevin Ilhan,Selcuk Ilhan,Solmaz Susam,Engin Sahna Emre Mutlu*,Necip Ilhan,Nevin Ilhan,Selcuk Ilhan,Solmaz Susam,Engin Sahna
  
  There is no sufficiently investigation about the effects of novokinin, AT2 receptor agonist, on target molecules associated with organ pathology including ADMA, NADPH oxidase and Rho kinase. In this study we investigated the effects of novokinin, perindopril and losartan on Rho kinase, ADMA, NADPH oxidase at renal tissue blood pressure, in L-NAME and salt induced hypertension. Additionally, a1-adrenergic-induced contraction, ach-induced dilator responses in vessels obtained from hypertensive and pharmacological therapy groups were studied.In this study we investigated the effects of novokinin, perindopril and losartan on blood pressure, Rho kinase, ADMA, NADPH oxidase at renal tissue in L-NAME and salt induced hypertension. Additionally, a1-adrenergic-induced contraction, ach-induced dilator responses in vessels obtained from hypertensive and pharmacological therapy groups were studied. .. View More»
  DOI: 10.4172/2161-1459.1000197

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