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EN Smirnova
EN Smirnova
Serbia
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Research Article
Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome
Author(s): SG Shulkina, EN Smirnova and MV TrushinSG Shulkina, EN Smirnova and MV Trushin
The aim of this study was to evaluate the effect of adipokines on the formation of kidney disease in patients with obesity and hypertension. The survey included 87 patients with hypertension (stage 1-2): with obesity (n 5 67), without obesity (n 5 20). In control group, there were 25 obese patients without hypertension and metabolic changes and 30 healthy persons (mean age 48.2 6 2.4 years). We investigated the relationship between leptin, resistin, and integral indices of renal damage (glomerular filtration rate [GFR], microalbuminuria [MAU], vascular endothelial growth factor [VEGF]). In obese patients without clinical signs of renal disease, a decrease in GFR was detected in 44.7% of respondents. Levels of leptin and resistin, markers of renal damage (MAU, VEGF), were significantly higher in the group of obesity. Correlation analysis showed the existence of a high degree of direct .. View More»
DOI: 10.4172/0974-8369.1000360