Journal of Microbial & Biochemical Technology

Elnaz Mehdizadeh Aghdam

Publications

• Research Article
  Riboswitches as Potential Targets for Aminoglycosides Compared with rRNA Molecules: In Silico Study
  Author(s): Elnaz Mehdizadeh Aghdam, Mohammad Esmaeil Hejazi, Mohammad Saeid Hejazi and Abolfazl BarzegarElnaz Mehdizadeh Aghdam, Mohammad Esmaeil Hejazi, Mohammad Saeid Hejazi and Abolfazl Barzegar
  
  Riboswitches are cis acting riboregulaters in non-coding region of the mRNAs. Their possible contribution in antibiotic targeting especially for FMN, TPP and lysine riboswitches in bacteria has been revealed since a decade ago. Regarding some studies on the possibility of the interaction between aminoglycosides and the artificial riboswitches, in this study we attempted to evaluate the binding potential of different types of aminoglycosides including gentamicin, amikacin, kanamycin, neomycin, tobramaycin, sisomicin and paromomycin with various classes of riboswitches using computational methods. Applying Auto Dock vina, it was shown that the binding energy of each kind of riboswitches with different types of aminoglycosides (riboswitches/aminoglycosides) is almost similar or sometimes more than .. View More»
  DOI: 10.4172/1948-5948.S9-002

  Abstract PDF