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El Sayed AAY
El Sayed AAY
Egypt
Publications
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Research Article
Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations Using Three Different Spectrophotometric Methods
Author(s): Naggar AH, Elnasr TAS, Sayed Ali AS, Kotb A and El Sayed AAYNaggar AH, Elnasr TAS, Sayed Ali AS, Kotb A and El Sayed AAY
Three simple, selective, accurate and precise spectrophotometric methods were developed for the determination of Metoclopramide Hydrochloride (MCP) in dosage forms. The first method (Method A) is based on coupling reaction of diazotized MCP with 2,5-diphenyl-2,4-dihydro-pyrazol-3-one (DPP) in alkaline medium to form azo dye. The second method (Method B) is based on Schiff’s base formation reaction between MCP and 4-hydroxybenzaldehyde (HBD). The last method (Method C) is based on the formation of colored ion–pair complex from the reaction of MCP with Eosin Y (ESN). Beer’s law was obeyed in the concentration range of 1.35-40.37, 1.01-5.05 and 1.01-10.09 μg/mL MCP at 426, 386 and 543 nm with molar absorptivity of 1.51×104 L mol-1 cm-1, 2.10×104 L mol-1 cm-1 and 3.34×10.. View More»
DOI: 10.4172/2153-2435.1000538