Journal of Allergy & Therapy

Eijin Sutoh

Publications

• Review Article
  Hypothetical Mechanism of Aspirin-Exacerbated Respiratory Disease Based on Recent Investigations of Gene Polymorphisms in Japanese Patients
  Author(s): Motohiro Kurosawa, Yujin Sutoh, Tatsuo Yukawa, Soichiro Hozawa and Eijin Sutoh Motohiro Kurosawa, Yujin Sutoh, Tatsuo Yukawa, Soichiro Hozawa and Eijin Sutoh
  
  Aspirin-exacerbated respiratory disease (AERD) is characterized by severe asthmatic attack after taking aspirin and/or nonsteroidal anti-inflammatory drugs (NSAIDs). The typical patient with AERD is an adult who develops refractory chronic rhinitis in the third or fourth decade of life. Natural history and clinical features of AERD indicates that during the evaluation of chronic rhinitis persistent bronchial asthma develops, and finally after exposure to NSAID acute respiratory reactions begin to occur. The inhibitory action of aspirin and/or NSAIDs on cyclooxygenase activity may cause diversion to the 5-lipoxygenase pathway, which leads to the overproduction of cysteinyl leukotrienes (LTs). Thus, a general consensus exists that increased levels of cysteinyl LTs are key inflammatory mediators in AERD. As aspirin intolerance is found in a specific population, genetic predisposition has.. View More»
  DOI: 10.4172/2155-6121.1000230

  Abstract PDF