Journal of Bioequivalence & Bioavailability

Eduardo Hernandez

Publications

• Research Article
  Bioavailability of Two Different Coated-Tablet Formulations of Valacyclovir of Two Different Strengths (500 mg and 1000 mg) in Healthy Mexican Adult Volunteers
  Author(s): Eduardo Hernandez, Iván Alvarado, Sara Castillo, Ericka López-Bojórquez, Sofía del Castillo-García, Clara Espinosa-Martínez, Victoria Burke-Fraga and Mario González-de la ParraEduardo Hernandez, Iván Alvarado, Sara Castillo, Ericka López-Bojórquez, Sofía del Castillo-García, Clara Espinosa-Martínez, Victoria Burke-Fraga and Mario González-de la Parra
  
  Valacyclovir is a prodrug of acyclovir. In Mexico, it is indicated for the treatment of herpes zoster and herpes simplex infections. The aims of these 2 studies were to compare the bioavailability and to determine the bioequivalence of 2- test formulations containing 500 mg and 1000 mg of oral valacyclovir. Two separate, single-dose, open-label, randomized, 2-period, crossover studies were conducted. For each study a different set of 26 subjects of both genders was enrolled, with a 7-day washout period. In both studies, the study formulations were administered after a 10-hour overnight fast. For pharmacokinetic analysis, blood samples were drawn at baseline, 0.25, 0.50, 0.75, 1, 1.25, 1.50, 1.75, 2, 3, 4, 6, 8, 12 and 24 hours after administration. Plasma concentrations of acyclovir .. View More»
  DOI: 10.4172/jbb.1000108

  Abstract PDF