Advances in Pharmacoepidemiology and Drug Safety

Dra. Karelia Cosme

Publications

• Research Article
  Study of Oral Acute Toxicity/Pathogenicity of the Tsukamurella Paurometabola Active Agent of the Biological Nematicide C-924 (Hebernem®)
  Author(s): Lizet Aldana Velazco, Dania Bacardí Fernández, Odette Beiro Castro, Dra. Karelia Cosme, Lic. Yamilka Ramírez Núñez, Carmen Valenzuela Silva, Nelson Merino García, Juan Fco. Sánchez de la Morena, Lic Lorelys Milá Cáceres, Téc. Rubén Amaya Izquierdo, Téc. José Suárez Alba, Onelio Carballo, Jesús Mena Campos and Carlos BorrotoLizet Aldana Velazco, Dania Bacardí Fernández, Odette Beiro Castro, Dra. Karelia Cosme, Lic. Yamilka Ramírez Núñez, Carmen Valenzuela Silva, Nelson Merino García, Juan Fco. Sánchez de la Morena, Lic Lorelys Milá Cáceres, Téc. Rubén Amaya Izquierdo, Téc. José Suárez Alba, Onelio Carballo, Jesús Mena Campos and Carlos Borroto
  
  The nematodes constitute one of the most phyto-pathogenic species in agriculture, using chemical and biological control agents. The Tsukamurella paurometabola is a bacterial strain with possibilities of being used as a nematicide; thus, it is necessary to evaluate the effect of its administration in lab animals with the objective of estimating its toxicity, infectivity and pathogenicity. To accomplish this aim, it was administered a single dose of 108 ufc/animal with T. paurometabola C-924 in three variants as an active agent, final product (HEBERNEM®) and inactive final product by oral route to Sprague-Dawley rats of both sexes, and their respective placebos. The analyzed variables were: clinical observation, feed and water consumption, body weight, infectivity (tissues, organs and biological fluids), clearing or persistence (faeces collection) and gross and micr.. View More»
  DOI: 10.4172/2167-1052.1000106

  Abstract PDF