Journal of Pharmacogenomics & Pharmacoproteomics

Domarkienė I

Publications

• Research Article
  The Prevalence of Rare Variants Potentially Important for the Response to Medicines Used for CVD Treatment in the Lithuanian Population
  Author(s): Pranculis A, Rančelis T, AmbrozaitytÄ— L, UktverytÄ— I, DomarkienÄ— I, BurokienÄ— N, KučinskienÄ— ZA and Kučinskas V Pranculis A, Rančelis T, Ambrozaitytė L, Uktverytė I, Domarkienė I, Burokienė N, Kučinskienė ZA and Kučinskas V
  
  Cardiovascular disease (CVD) is one of the leading causes of death among Europeans and around the world. Major factors that are considered relevant for the efficacy or adverse drug reactions (ADRs) caused by drugs used for CVD treatment have been identified through GWAS studies mostly using low density common variant genotyping arrays. In this study whole exome sequencing (WES) was carried out to identify genomic variants relevant for CVD treatment. The study group included 98 (49 males and 49 females) self-reported healthy unrelated individuals from the Lithuanian population with at least three generations of Lithuanian ethnicity and residency in the same ethnolinguistic region. After performing WES genetic loci of 55 genes that were reported as relevant to the efficacy or ADRs caused by drugs used for CVD treatment were analyzed using LifeScopeTM and ANNOVAR software. The analysis of s.. View More»
  DOI: 10.4172/2153-0645.1000157

  Abstract PDF