Journal of Bioequivalence & Bioavailability

Dolores RC

Publications

• Research Article
  Comparative Bioavailability Study of Two 81 mg Coated Tablet Formulations of Acetylsalicylic Acid in Fasting Healthy Volunteers
  Author(s): Dolores RC, Antunes NJ, Moreno R, Di Vaio P, Magli E and De Nucci G Dolores RC, Antunes NJ, Moreno R, Di Vaio P, Magli E and De Nucci G
  
  Introduction: Low-dose acetylsalicylic acid is used as antithrombotic agent and the enteric-coated formulations are widely used to minimize the gastrointestinal side effects. Aim: To compare the bioavailability of two acetylsalicylic acid formulations (Ecasil-81®, 81 mg coated tablet) in fasting healthy volunteers. Methods: Healthy volunteers (n=16) were recruited to a monocentric, open label, randomized, two-way crossover pharmacokinetic study, with seven days washout period between the treatments. They received a single 81 mg oral dose of a test (new formulation) or a standard reference formulation of acetylsalicylic acid (Ecasil-81®) after about 8 h fasting. Blood samples were collected over a period of 36 h. The salicylic acid plasma concentration was evaluated by high-performance liquid chromatography .. View More»
  DOI: 10.4172/jbb.1000348

  Abstract PDF