Journal of Carcinogenesis & Mutagenesis

Dina Hisham Mohamed

Publications

• Research Article
  Role of Adipose-Derived Stem Cells in Restoring Ovarian Structure of Adult Albino Rats with Chemotherapy-Induced Ovarian Failure: A Histological and Immunohistochemical Study
  Author(s): Faten Riad Omar, Noha Mohamed Afifi Amin, Hala Ahmed Elsherif and Dina Hisham Mohamed Faten Riad Omar, Noha Mohamed Afifi Amin, Hala Ahmed Elsherif and Dina Hisham Mohamed
  
  Background and objectives: Damage to the reproductive system is one of the most devastating effects of chemotherapeutic treatment. It is frequently associated with premature ovarian failure (POF). Therefore, this study was planned to evaluate the therapeutic effectiveness of Adipose-Derived Stem Cells (ADSCs) in a rat model of chemotherapy-induced ovarian failure. Methods and results: This study was carried out on forty adult female albino rats. They were divided into: Group I Control Group (n=8) received a vehicle of phosphate buffered saline (PBS) solution. Group II in which ovarian failure (OF) was induced using combined cyclophosphamide/busulfan therapy and were sacrificed after one week (gIIa n=8) and after five weeks (gIIb n=8). Group III in which rats received ADSCs after chemotherapy and were sacrificed after one week (gIIIa n=8) and after four weeks (gIIIb n=8). Blood .. View More»
  DOI: 10.4172/2157-2518.1000254

  Abstract PDF