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Denkova P
Denkova P
Bulgaria
Publications
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Research Article
Cytotoxic Effects of Some N-Substituted-2-Amino-1H-Benzimidazoles
Author(s): Mavrova AT, Diana Wesselinova, Tsenov JA and Denkova PMavrova AT, Diana Wesselinova, Tsenov JA and Denkova P
The cytotoxic activity of previously synthesized is (benzimidazol-2-yl) amines was evaluated on two cancer celllines:human epithelial colorectal carcinoma HT-29 (American Type Culture Collection HTB-38), breast cancer cells with epithelial-like morphology MDA-MB 231 (American Type Culture Collection ATCC HTB-26), and on normal spleen cells as well as. Indicative cytotoxic activity was ascertained for N-1H-benzimidazol-2-yl-1-propyl-1H-benzimidazol-2-amine 15, 1-propyl-N-(1-propyl-1H-benzimidazol-2-yl)-1H-benzimidazol-2-amine 21 and 1-methyl-N-(1-propyl-1H-benzimidazol-2-yl)-1H-benzimidazol-2-amine18 against the cellular line HT-29. The estimated IC50values were 0.91, 1.92 and 1.98 μM respectively. The same compounds exhibited comparatively high antiproliferative activity against MDA-MB-231 cells. The realized IC50 values were in the range 0.006 � 1.48 μM. Compounds 14, 16, 17,.. View More»
DOI: 10.4172/jbb.10000112