Journal of Bioequivalence & Bioavailability

De-Lu Ma

Publications

• Research Article
  Study on Pharmacokinetics and Bioequivalence of Cefdinir Dispersible Tablet in Healthy Chinese Volunteers
  Author(s): Cai-Li Zhang, Jian-Jie Jiao, Yan-Na Wu, Jun-qiu Song, Wei-Zhen Gao, De-Lu Ma and Jian-Shi LouCai-Li Zhang, Jian-Jie Jiao, Yan-Na Wu, Jun-qiu Song, Wei-Zhen Gao, De-Lu Ma and Jian-Shi Lou
  
  Aim: To evaluate the pharmacokinetics and bioequivalence of cefdinir dispersible tablet with cefdinir capsule in healthy Chinese volunteers. Methods: cefdinir dispersible tablet and cefdinir capsule were used as the test and reference preparations respectively. Two randomized, comparative two-way crossover studies were conducted in 18 healthy Chinese male volunteers. Test preparation 200mg, reference preparation 200mg were administered once orally to the volunteers fasting overnight, with 5 days washout period between the doses of the test and reference preparations. Before dosing blood sample, after dosing several blood samples were collected for a period of 12 hours. The plasma concentrations of cefdinir at different times were determined by high performance liquid chromatogrphy (HPLC) with ultraviolet (UV) assay. Pharmacokinetic parameters were calculated. Safety of the drug was ev.. View More»
  DOI: 10.4172/jbb.1000070

  Abstract PDF