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Debmalya Barh
Debmalya Barh
India
Publications
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Case Report
Towards a Comprehensive Understanding of miRNA Regulome and miRNA Interaction Networks
Author(s): Joseph J Nalluri, Debmalya Barh, Vasco Azevedo and Preetam GhoshJoseph J Nalluri, Debmalya Barh, Vasco Azevedo and Preetam Ghosh
miRNAs are vital regulators of post transcriptional gene expression. Deregulation of miRNAs lead to susceptibility towards many diseases, especially cancers. Their complicated molecular mechanisms comprising of upstream transcriptions factors, downstream targets, functional and biological processes, and disease regulations are not fully comprehended yet. Hence, understanding the miRNA regulatory network comprehensively is pivotal to modulate its functions and develop miRNA therapeutics. At present, several independent databases and tools containing specific information about parts of a miRNA regulome exist in silo which prevents a holistic understanding of miRNA's molecular mechanism. Hence, integration of all scattered datasets in a cohesive manner in order to get an overarching understanding of the contributory influence and the effluence from the machinery of a miRNA regulome is cr.. View More»
DOI: 10.4172/2153-0645.1000160