Journal of Blood Disorders & Transfusion

Darshak Makadia

Publications

• Case Report
  Variable Manifestations of Severe Hypoprothrombinemia (Factor II Deficiency): 2 Cases
  Author(s): Sirisha Rani S, Darshak Makadia, Lokesh Lingappa, Nikit Shah and Ramesh KonankiSirisha Rani S, Darshak Makadia, Lokesh Lingappa, Nikit Shah and Ramesh Konanki
  
  Case 1 is a 28 months female child, who has been symptomatic from 8 month of age with multiple, painful bruises over legs once in 5 to 6 weeks. Her complete blood picture was normal.PT and APTT were prolonged with normal fibrinogen and liver function. Case 2, became symptomatic from day 2 of life. He was treated for blood stained vomiting and black coloured stool and severe anaemia. Second episode was subdural hemorrhage and seizures. Investigations revealed abnormal PT and APTT with normal fibrinogen and liver function. Hereditary prothrombin deficiency is one of the rare congenital coagulation defect encountered in clinical practice. High index of suspicion is required to diagnose this condition with systematic approach as the facility to check factor 2 levels are not freely available in many centres. Bleeding manifestations are dependent on factor level. Children with severe defici.. View More»
  DOI: 10.4172/2155-9864.1000192

  Abstract PDF