Journal of Nanomedicine & Nanotechnology

Danni Ramdhani

Publications

• Research Article
  Formulation and Characterization of Chondroitin Sulfate Nanoparticle with Chitosan as Polymer and Kappa Carrageenan as Crosslinker Using the Ionic Gelation Method
  Author(s): Danni Ramdhani Danni Ramdhani
  
  Chondroitin sulfate is a widely used dietary supplement formulations, effective for the treatment of osteoarthritis. In oral preparations, chondroitin sulfate has low bioavailability. The alternative to improve bioavailability of a drug is by using nanoparticle technology. This study was aimed to formulate and characterize chondroitin sulfate nanoparticles with chitosan as polymer and kappa carrageenan as crosslinker. Nanoparticles were prepared by using ionic gelation method that was based on the electrostatic interaction between opposite charges. Characterization of nanoparticles were performed by measuring pH, particle size, polydispersity index, zeta potential, and examination of infrared spectrum. The results showed that F1 containing 0.1% chitosan, 0.1% chondroitin sulfate, and 0.05% kappa carrageenan at volume ratio of 10:1:1 was the best formula with an average particle size 5.. View More»
  DOI: 10.4172/2157-7439.S8-005

  Abstract PDF