Daniel Tonduangu
France
Case Report
Fatal Delayed Hemolytic Transfusion Reaction and Hyperhemolysis without Detectable Alloantibodies or Autoantibodies in a Patient with Sickle Cell Disease: A Case Report and Literature Review
Author(s): Basile Nsimba, Anoosha Habibi, France Pirenne, Pablo Bartolucci, Daniel Tonduangu, Christophe Duvoux, Nicolas De Prost, Maud Marcandetti, Armand Mekontso-Dessap, Frédéric Galactéros, Pascal Morel
Basile Nsimba, Anoosha Habibi, France Pirenne, Pablo Bartolucci, Daniel Tonduangu, Christophe Duvoux, Nicolas De Prost, Maud Marcandetti, Armand Mekontso-Dessap, Frédéric Galactéros, Pascal Morel
Background: Sickle cell disease (SCD) is one of the most commonly inherited diseases worldwide and one of the most frequently occurring genetic disorders in France. Delayed hemolytic transfusion reaction (DHTR) is a classic complication in patients with SCD who undergo blood transfusions, and this condition may lead to hyperhemolysis syndrome (HS). DHTR is described as a transfusion complication and is often associated with anti-RBC antibodies.
Case report: We report the death of a 47-year-old man of Martinican origin, with sickle cell disease (SCD) and no history of alloimmunization, who was admitted to the Sens Medical Center in July 2015 due to a vaso-occlusive crisis (VOC). An antibody screening test based on the gel technique was conducted and no anti-RBC antibodies were detected. The patient was readmitted with a VOC two days after dis.. View More»
DOI:
10.4172/2155-9864.1000388