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Chu Chen
Chu Chen
China
Publications
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Review Article
Long Noncoding RNAs and Human Osteosarcoma
Author(s): Arshad Ali, Lifang Hu, Airong Qian,Chu Chen and Tuanmin Yang Arshad Ali, Lifang Hu, Airong Qian,Chu Chen and Tuanmin Yang
Osteosarcoma is the most commonly diagnosed malignancies in children and adolescents, pathologically characterized by spindle cells and deviant osteoid formation. Although significant evidences in therapeutic strategies have been accomplished, the conclusion is still unclear for the critical metastatic or persistent osteosarcoma. Therefore, it is essential to develop novel and effective biomarkers or therapeutic targets for diagnosis of osteosarcoma. Long noncoding RNAs (lncRNAs), as a novel class of noncoding RNA, are composed of transcripts longer than 200 nucleotides and play critical roles in development and progression of various cancers including osteosarcoma. LncRNAs are mainly involved in different biological process such cell growth, transcription, translation, epigenetic regulation, splicing, chromosome dosage compensation, imprinting, nuclear, cytoplasmic trafficking and ce.. View More»
DOI: 10.4172/2157-7633.1000418