Journal of Blood Disorders & Transfusion

Christian Klein

Publications

• Review Article
  Advances in Bispecific Antibodies Engineering: Novel Concepts for Immunotherapies
  Author(s): Ivana Spasevska, Minh Ngoc Duong, Christian Klein and Charles DumontetIvana Spasevska, Minh Ngoc Duong, Christian Klein and Charles Dumontet
  
  Bispecific antibodies are emerging as novel approach for immunotherapies by combining two antigen-recognizing elements into a single construct that is able to simultaneously bind to two distinct targets. Bispecific antibodies can be applied to recruit immunological effector cells for killing of tumor cells or to simultaneously block two signaling pathways or cytokines. Subsequently, they have prompted significant interest for a number of therapeutic applications, both in cancer and in other indications. The growing interest in therapeutic antibodies along with the rapid progress in antibody engineering have yield a multitude of bispecific antibodies formats and derived molecules that differ in size, shape and function. Presently, two major classes of bispecific antibodies are most widely studied: immunoglobulin-like and small single chain Fv (scFv)-based bispecific antibodies. This re.. View More»
  DOI: 10.4172/2155-9864.1000243

  Abstract PDF