Journal of Bioequivalence & Bioavailability

Byran Gowramma

Publications

• Research Article
  Pharmacokinetic Evaluation of Newly Developed Oral Immediate Release and Sustained Release Dosage Forms of Losartan Potassium
  Author(s): Basuvan Babu, Subramania Nainar Meyyanathan, Byran Gowramma, Selvadurai Muralidharan, Kannan Elango and Bhojraj SureshBasuvan Babu, Subramania Nainar Meyyanathan, Byran Gowramma, Selvadurai Muralidharan, Kannan Elango and Bhojraj Suresh
  
  The aim of our present study is to develop oral sustained release dosage form for Losartan Potassium (SS) with wet granulation technique. Xanthan gum with additives MCC PH101 was used for the present study. The dissolution study is carried out. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and fillers. The pharmacokinetic parameters including AUC 0–t , AUC 0–∞ , C max , T max , T 1/2 , and elimination rate constant ( K el ) were determined from plasma concentration of both formulations of Immediate Release (Losartan Potassium 1.75 mg tablets) and Sustained Release (Losartan Potassium 3.5 mg tablets). The absorption of drug from the sustained release tablets was significantly higher than that for the reference Losartan Potassium tablet because of longer half-life and lower elimination. Different pharmacokineti.. View More»
  DOI: 10.4172/jbb.1000124

  Abstract PDF