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Brian I. Carr
Brian I. Carr
Izmir International Biomedicine and Genome Institute,
35340 Balçova, Izmir
Turkey
Publications
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Review Article
Platelets, Microenvironment and Hepatocellular Carcinoma
Author(s): Yeliz Yilmaz, Esra Erdal, Nese Atabey and Brian I. Carr Yeliz Yilmaz, Esra Erdal, Nese Atabey and Brian I. Carr
Hepatocellular carcinoma (HCC) is the commonest type of liver cancer and has a high mortality rate. Currently treatment options are limited and new therapies are urgently needed. Platelets are enucleated small cells, derived from mature megakaryocytes and besides their role in thrombosis; they actively take part in carcinogenesis and metastasis. Platelet number in the blood is associated with disease progression, overall survival and HCC subgrouping. Both thrombocytosis and thrombocytopenia are associated with HCC phenotype and size, related with other factors like cirrhosis background. Platelet counts and also platelet-to-lymphocyte ratio (PLR) and neutrophil-tolymphocyte ratio (NLR) are considered in decision making in management. Since platelets also take up nucleotides and cytokines from tumor cells, isolating and studying platelets might provide valuable information for understan.. View More»
DOI: 10.4172/2161-1009.1000281