Biology and Medicine

Brian Duggan

Publications

• Research Article
  Urinary Thrombomodulin Levels Were Significantly Higher Following Occupational Exposure to Chemicals, In The Presence of Dipstick Protein, But Not in the Presence of Dipstick Blood
  Author(s): Mark W. Ruddock, Ricardo de Matos Simoes, Declan O’Rourke, Brian Duggan, Michael Stevenson, Hugh F. O’Kane, David Curry, Funso Abogunrin, Frank Emmert-Streib, Cherith N. Reid, Perry Maxwell, Ken Arthur, Michael Mallon, Gail Carson, Grace Kennedy and Kate E. WilliamsonMark W. Ruddock, Ricardo de Matos Simoes, Declan O’Rourke, Brian Duggan, Michael Stevenson, Hugh F. O’Kane, David Curry, Funso Abogunrin, Frank Emmert-Streib, Cherith N. Reid, Perry Maxwell, Ken Arthur, Michael Mallon, Gail Carson, Grace Kennedy and Kate E. Williamson
  
  Currently, there are no biomarkers which can identify patients with an increased risk of developing urothelial cancer as a result of occupational chemical exposure. The aim of this study was to evaluate the relationships between final diagnosis and 22 biomarkers measured in urine, serum and plasma collected from 156 hematuric patients. Fourteen of the 80 patients (17.5%) with urothelial cancer and 13/76 (17.1%) of the controls were deemed to have a history of chemical exposure. We applied Fisher's exact tests to explore associations between chemical exposure and final diagnosis, and tumor stage and grade, where applicable; ANOVA and t-test to compare age across patients with and without chemical exposure; and Zelen’s exact test to evaluate relationships across final diagnosis, chemical exposure and smoking. Following pre-selection of biomarkers using.. View More»
  DOI: 10.4172/0974-8369.1000260

  Abstract PDF