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Bouzina H
Bouzina H
The Hemodynamic Lab, The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine,
Lund
Sweden
Publications
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Research Article
Plasma sFlt-1 Fluctuations in Response to Pulmonary Arterial Hypertension Treatment
Author(s): Bouzina H*, Nielsen S, Scheele C and Rådegran GBouzina H*, Nielsen S, Scheele C and Rådegran G
Background: Pulmonary Arterial Hypertension (PAH) is characterized by vasoconstriction and remodeling of distal pulmonary arteries, which result in increased Pulmonary Vascular Resistance (PVR) and right ventricular overload. In the present study, we measured plasma fluctuations of nine proteins, involved in inflammation or tyrosine kinase signaling, in PAH patients, to assess their value as biomarkers of treatment response. Methods: Plasma vascular endothelial growth factor A and D, soluble fms-like tyrosine kinase-1 (sFlt-1), placenta growth factor, fibroblast growth factor 2, angiopoietin-1 receptor, interleukin (IL)-6 and -8 and tumor necrosis factor α were determined by multiplex immunoassays in 21 treatment-naïve PAH patients at baseline and at first and second clinical checkups. Results: From baseline.. View More»
DOI: 10.4172/2329-6607.1000207