Botskariova S
Greece
Review Article
Atopic Dermatitis: Insights on Pathogenesis, Evaluation and Management
Author(s): Karagiannidou A, Botskariova S, Farmaki E, Imvrios G and Mavroudi A
Karagiannidou A, Botskariova S, Farmaki E, Imvrios G and Mavroudi A
Background: Atopic Dermatitis (AD) is a highly pruritic chronic inflammatory skin disease that commonly presents during early childhood. Several studies indicate that the disease is very common in western world with lifetime prevalence in children of 10% to 20%.
Data sources: We make recommendations regarding the evaluation and management of AD in children based on systematic literature searches using the best-available evidence from PubMed, Medline, Google Scholar, NICE, the American Academy of Dermatology and the World Allergy Organization.
Results: AD has an immunologic basis. Both innate and adaptive immune responses are impaired in AD patients. Intense pruritus is a hallmark of the disease which leads to extensive scratching and further breakdown of the skin barrier. Treatment of AD may be topical or systemic. Topical corticosteroids and calcineurin inhibitors.. View More»
DOI:
10.4172/2155-6121.1000195