Bekir İnan
Turkey
Research Article
Investigation of the Impact of Flaxseed (Linum Usitatissimum) on the Lower Extremity Ischemia/Reperfusion Injury in a Hypercholesterolemic Rat Model
Author(s): Melike Elif Teker, Bekir Inan and Oznur InanMelike Elif Teker, Bekir Inan and Oznur Inan
Introduction: Ischemia is a condition in which the circulation fails to provide the oxygen and other metabolites required by the tissue, and to eliminate the waste products. Reperfusion is the recovery of blood flow and oxygen to a hypoxic tissue. The aim of this study is to investigate the effect of flaxseed (L. Usitatissimum) in a hyper cholesterolemic rat model of lower extremity ischemia-reperfusion injury.Material and method: 38 female Wistar rats weighing 200 to 250 grams were used in the study. The rats were assigned into 4 groups as follows: Group 1 (control, normal diet, n:8); Group 2 (40 mg/kg fed by body lignan complex, n:10), Group 3: (fed by 0.1% cholesterol containing diet, n:10), Group 4 (fed by 0.1% cholesterol containing diet+40 mg/kg body lignan complex, n:10). Ischemia was modeled by performing ligation of the left fe.. View More»
DOI:
10.4172/2329-6925.1000338