Baló-Banga JM
H-1062 Budapest, Podmaniczky u. 109-111
Hungary
Review Article
In Vitro Diagnosis of Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs
(NSAID) Comparison of Two Methods
Author(s): Baló-Banga JM and Schweitzer K
Baló-Banga JM and Schweitzer K
Objective: Current concept distinguishes between cross intolerance (non-immune) and single or multiple hypersensitivity based (immune) adverse reactions of non-steroidal anti-inflammatory drugs (NSAID) due to their potential to inhibit cyclooxygenase (COX) isoenzymes (COX-1, COX-2). Recently we described a rapid IL-6 release assay using blood mononuclear cells of patients with various clinical forms of drug hypersensitivity. Here we present data of a comprehensive analysis if the IL-6 release test and the classical IgE immuno-assay for their sensitivity in cases with adverse reactions to NSAIDs grouped according to the new clinical classification.
Methods: Total and specific serum IgE against 9 different HSA coupled-NSAIDs were determined by manual ELISA tests (55 cases) and compared to drug-specific release from preformed IL-6 pool of PBMCs.. View More»
DOI:
10.4172/2155-6121.1000255