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B Singha
B Singha
India
Publications
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Research Article
Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents
Author(s): Neelam Sharmaa, Jyotsna Suric, BK Chandana, B Singha, Naresh Sattib, A Prabhakar, BD Gupta, Mowkshi Khullara and Zabeer Ahmeda Neelam Sharmaa, Jyotsna Suric, BK Chandana, B Singha, Naresh Sattib, A Prabhakar, BD Gupta, Mowkshi Khullara and Zabeer Ahmeda
The use of Vitex negundo Linn. (Family: verbenaceae) is well documented in ayurveda and traditional Indian system of medicine for variety of diseases and liver ailments. The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from Vitex negundo Linn. against acetaminophen (APAP) and galactosamine (GalN) hepatotoxicity. SF was tested at doses 12.5, 25, 50 and 100mg/kg, p.o. using both prophylactic and curative treatment schedule against APAP and GalN hepatotoxicity in mice and rats respectively. Isolated markers agnuside and negundoside were tested against APAP toxicity. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and albumin were estimated in serum and triglycerides (TG), total protein, glutathione (GSH) and lipid peroxidation (LP) in liver homog.. View More»
DOI: 10.4172/2161-1009.1000267