Journal of Vaccines & Vaccination

B. Baradaran

Publications

• Research Article
  Development of Leptospira Killed Whole Culture Vaccine Using Different Adjuvants and Evaluation of Humoral Immune Response in Hamsters
  Author(s): R. Banihashemi, B. Baradaran, M. Tebianian, J. Majidi, A. Jabbari, S. Jalali, H.mohammadpour, K. Tadayyon, M. Sekhavati, R Ghaderi and G. shokriR. Banihashemi, B. Baradaran, M. Tebianian, J. Majidi, A. Jabbari, S. Jalali, H.mohammadpour, K. Tadayyon, M. Sekhavati, R Ghaderi and G. shokri
  
  Leptospirosis is an acute infectious disease caused by Leptospira spp. that produces a broad range of health problems mainly in developing world. In several affected countries, a major attempt has been begun to find a potent and effective vaccine. This is while; the available vaccines neither perused immunological memory nor confer cross-protection. Four-week-old male hamsters were subcutaneously inoculated with four-leptospiral vaccine and four-control adjuvant through a triple-injection regiment at fortnightly intervals. Animals were bled through the saphenous vein weekly until the seventh week. We have demonstrated that adjuvant plays a fundamental role in the type and extent of the immune responses raised by leptospiral vaccination. We strongly recommend selection of alum in any formulation of leptospiral vaccine. .. View More»
  DOI: 10.4172/2157-7560.1000185

  Abstract PDF