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Azza Aziz Moustafa
Azza Aziz Moustafa
Egypt
Publications
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Research Article
Stability Indicating Validated Chromatographic Methods for Determination of Buflomedil in Presence of its Degradation Products
Author(s): Hesham Salem, Azza Aziz Moustafa, Maha Hegazy and Omnia Ali Hesham Salem, Azza Aziz Moustafa, Maha Hegazy and Omnia Ali
Simple, sensitive, selective and precise stability-indicating thin-layer chromatographic (TLC) and high-performance liquid chromatographic (HPLC) methods for the determination of Buflomedil (BFM) in pharmaceutical tablets were developed and validatedas per the International Conference on Harmonizationguidelines. The TLC method employs aluminum TLCplates precoated with silica gel 60F254 as the stationary phase and Butanol: ammonia: triethylamine (8:0.5:0.5, v/v/v) as the mobile phase to give compact spots for Buflomedil (Rf=0.55) and its degradation product (Rf=0.05), the chromatogram was scanned at 272 nm. The HPLC method utilizes a C18 column and amobile phase consisting of methanol: water: acetonitrile: triethylamine (50:30:20:0.4, v/v, pH 6.5) at a flow rate of 0.7 mL min-1 for the separation of Buflomedil (tR=3.76) and its degradation product (tR=2.117). Quantitation was achieved wit.. View More»
DOI: 10.4172/2153-2435.1000233