Journal of Liver

Ayah M.H. Gowifel

Publications

• Research Article
  Protective Effect of Grape Seed Extract and/or Silymarin Against Thioacetamide-induced Hepatic Fibrosis in Rats
  Author(s): Somaia A. Nada*,Ayah M.H. Gowifel,Ezz El-Din S. El-Denshary,Abeer A. Salama,Mona G Khalil,Kawkab A Ahmed Somaia A. Nada*,Ayah M.H. Gowifel,Ezz El-Din S. El-Denshary,Abeer A. Salama,Mona G Khalil,Kawkab A Ahmed
  
  The aim of the present study was designed to evaluate the hepatoprotective and antioxidant potentials of GSE (100 and 200 mg/kg) and/or silymarin against TAA-induced liver fibrosis in rats. This study was designed to investigate the protective effect of grape seed extract (GSE) and/or silymarin against thioacetamide (TAA)-induced hepatic fibrosis in Sprague-Dawley rats. Mature male Sprague-Dawley rats were divided into 7 equal groups (8 rats each) and treated as follows: Group 1, kept as control group and orally given saline; groups 2-7 were injected intraperitoneally (i.p.) with TAA (100 mg/Kg) twice weekly for 6 weeks to induce hepatic fibrosis. Group 2, kept as control positive; groups 3-5 were administered daily oral doses of silymarin (50 mg/kg), GSE (100 mg/kg) and GSE (200 mg/kg), respectively. While groups 6-7 were administered combined treatments of silymarin and GS.. View More»
  DOI: 10.4172/2167-0889.1000178

  Abstract PDF