Journal of Blood Disorders & Transfusion

Attila Frigyesi

Publications

• Research Article
  Effects of High Dose Fibrinogen on in vitro Haemodilution with Different Therapeutic Fluids
  Author(s): Eric Lidgard, Attila Frigyesi and Ulf Schött Eric Lidgard, Attila Frigyesi and Ulf Schött
  
  Background: Therapeutic fluids used in intensive care can have profound effects on coagulation, not only by dilution itself but also by other more complicated interactions. The aim of this in vitro study was to monitor the extent of dilutive coagulopathy induced by the most common therapeutic fluids and to attempt normalization of haemostasis by fibrinogen addition. Methods: 8 patients were recruited from the intensive care unit. Native whole blood was drawn, diluted by 50% with 9 different fluids, and run through a Sonoclot Analyzer. This was then repeated with high dose fibrinogen (corresponding to an in vivo dose of 8g/70kg) added to the dilutions. The fluids used were Voluven, Venofundin, Volulyte, Tetraspan, Albumin 5%, Macrodex, Gelofusine, Ringer’s acetate and NaCl. This covers the entire spectrum of fluids available in Sweden. Results: A significant i.. View More»
  DOI: 10.4172/2155-9864.1000106

  Abstract PDF