Journal of Blood Disorders & Transfusion

Asadifar M

Publications

• Research Article
  Platelet Aggregation Increased by Advanced Glycated Hemoglobin
  Author(s): Asadifar M, Bakhti M, Habibi-Rezaei M, Moosavi-Movahedi AA, Tabatabi MR, Ahmadinejad M and Badlou BAAsadifar M, Bakhti M, Habibi-Rezaei M, Moosavi-Movahedi AA, Tabatabi MR, Ahmadinejad M and Badlou BA
  
  Introduction: Many studies have provided strong evidence for an association between diabetes complications and an increase in platelet (PLT) reactivity. Though some metabolic abnormalities have been reported as the major causes of this reactivity and malfunction, the precise mechanism has not been fully elucidated. Aim: The aim of this study is to investigate the effect of advanced glycation end product of hemoglubin (AGE-Hb) on human PLT reactivity and malfunction. Materials and Methods: A solution of bovine hemoglobin was prepared with fructose in phosphate buffer. The solution was then sterilized and incubated under sterile conditions at 37°C in the dark. The control solution was prepared in the same way, but without fructose. Human PLTs were isolated and prepared from 15 healthy volunteers, men and women. Blood was collected in the morning from fasting healthy s.. View More»
  DOI: 10.4172/2155-9864.1000293

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