Pharmaceutica Analytica Acta

Arika WM

Publications

• Research Article
  In Vivo Antidiabetic Activity of the Aqueous Leaf Extract of Croton macrostachyus in Alloxan Induced Diabetic Mice
  Author(s): Arika WM, Abdirahman YA, Mawia MA, Wambua KF, Nyamai DM, Ogola PE, Kiboi NG, Nyandoro HO, Agyirifo DS, Ngugi MP and Njagi ENMArika WM, Abdirahman YA, Mawia MA, Wambua KF, Nyamai DM, Ogola PE, Kiboi NG, Nyandoro HO, Agyirifo DS, Ngugi MP and Njagi ENM
  
  The folklore reports from traditional medical practitioners that Croton macrostachyus has bioactivity against several diseases including diabetes mellitus have not been scientifically evaluated. The aim of this study was to determine the in vivo hypoglycemic activity of aqueous leaf extracts of this plant in male swiss white albino mice. Aqueous leaf extract of Croton macrostachyus was intraperitoneally and orally administered to alloxan (180.9 mg/ kg; intraperitoneally)-induced diabetic mice at different doses of 25 mg/kgbwt, 48.4 mg/kgbwt, 93.5 mg/kgbwt, 180.9 mg/kgbwt and 350 mg/kgbwt and the effects on blood glucose levels investigated. The treatments effects were compared with three controls (normal, diabetic and diabetic treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0.1 ml physiological saline or glibenclamide admini.. View More»
  DOI: 10.4172/2153-2435.1000447

  Abstract PDF