Journal of Liver

Appleby VJ

Publications

• Case Report
  Safety and Efficacy of Long Term Nasobiliary Drainage to Treat Intractable Pruritus in Cholestatic Liver Disease
  Author(s): Appleby VJ, Hutchinson JM and Davies MH Appleby VJ, Hutchinson JM and Davies MH
  
  Introduction: Cholestasis related pruritus, secondary to intrahepatic, and or extrahepatic biliary obstruction is a common manifestation in chronic liver disease. Pruritus is difficult to treat, and results often suboptimal. A stepwise medical approach is usually employed, followed by a trial molecular adsorbents recirculation system (MARS) in medication resistant cases. Pruritus resulting in reduced quality of life is a variant syndrome eligible for liver transplantation in the setting of preserved synthetic function. Aim: This case series describes the use of long term (LT)-NBD in three patients with intractable pruritus. This case series test the hypothesis that long-term NBD could be successfully used to alleviate cholestasis related pruritus, and prevent, or delay the need for liver transplantation. Method: LT.. View More»
  DOI: 10.4172/2167-0889.1000157

  Abstract PDF