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Journal of Bioequivalence & Bioavailability

Anna Plotka

Anna Plotka

2Pfizer Inc., 500 Arcola Rd, Collegeville, PA 19426, USA

Biography
Anna  Plotka, Pfizer Inc., 500 Arcola Rd, Collegeville, PA 19426, USA Background Pharmacokinetic (PK) studies suggest that talazoparib is primarily eliminated unchanged via renal excretion. The current study investigated how varying degrees of renal impairment may affect the PK of talazoparib, and evaluated the safety and tolerability of talazoparib, in patients with advanced solid tumors with/without renal impairmen.