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Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer

The Highs and Lows of FAIMS: Predictions and Future Trends for High Field Asymmetric Waveform Ion Mobility Spectrometry

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Citations : 10577

Journal of Nanomedicine & Nanotechnology received 10577 citations as per Google Scholar report

Journal of Nanomedicine & Nanotechnology
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Ali MM

Ali MM
Henry Ford Hospital,
One Ford Place, 2F, Detroit, MI 48202
Tanzania

Publications

  • Research Article
    Targeted Theranostic Approach for Glioma Using Dendrimer-Based Curcumin Nanoparticle
    Author(s): Gamage NH, Jing Li, Worsham MJ and Ali MM Gamage NH, Jing Li, Worsham MJ and Ali MM

    The delivery of anti-cancer agents to brain tumors represent a challenge because the blood-brain tumor barrier (BBTB) effectively limits the delivery of many agents. A new generation 3 (G3) dendrimer-based curcumin (Curc) conjugate was synthesized. The synthesized G3-Curc conjugate demonstrated full solubility in aqueous media. The in vitro study revealed that G3-Curc nanoparticles were internalized into glioma U-251 cells. Systemic delivery of G3-Curc conjugate led to preferentially accumulation in an orthotopic preclinical glioma model minimizing systemic toxic effect. Multicolor microscopy images of the tumor tissue showed that G3-Curc particles were internalized inside tumor cells selectively and further localized within nuclei. Enhanced bioavailability of G3-Curc conjugate was also observed with improved therapeutic efficacy against different cancers cells. .. View More»
    DOI: 10.4172/2157-7439.1000393

    Abstract PDF