Pharmaceutica Analytica Acta

Al-Hakimi AN

Publications

• Research Article
  Development Green Spectrophotometric Method for Determination of Sulfamethoxazole in Pure and Pharmaceutical Formulations
  Author(s): Al-Okab RA, Galil MSA and Al-Hakimi AN Al-Okab RA, Galil MSA and Al-Hakimi AN
  
  Green analytical chemistry is considered as a branch of the green chemistry and the main its goal is to achieve more green analysis in quality control laboratories through different direction, such as replacing or minimizing toxic reagents and modify or replace analytical techniques or methods with safer ones. We develop a simple, accurate and sensitive spectrophotometric procedure for determination of Sulfamethoxazole (SMX) using phenoxazine (PNZ) as green analytical reagent. The method is based on oxidation in aqueous mildly acidic medium primary amine group of SMX and coupling with PNZ in the prescient iron (III) to form a stable color having maximum absorption at 520 nm. Beer's law was obeyed in the range concentration of 0.1-6 mg/l and molar absorptivity 6.105 × 104 L.mol-1.cm-1. Sandell’s sensitivity 0.003 μg.cm-2 and detection limit (DL) 0.021 ppm. The direct.. View More»
  DOI: 10.4172/2153-2435.1000584

  Abstract PDF