Journal of Bioequivalence & Bioavailability

Alejandra Rosete- Reyes

Publications

• Research Article
  Bioavailability of Two Tablet Formulations of a Single Dose of Moxifloxacin 400 mg: An Open-Label, Randomized, Two-Period Crossover Comparison in Healthy Mexican Adult Volunteers
  Author(s): Gabriel Mendoza- Tamayo, Alejandra Rosete- Reyes, Roberto Medina- Santillán, Jessica González- Bañuelos, Clara Espinosa- Martínez, Victoria Burke- Fraga and Mario González-de la ParraGabriel Mendoza- Tamayo, Alejandra Rosete- Reyes, Roberto Medina- Santillán, Jessica González- Bañuelos, Clara Espinosa- Martínez, Victoria Burke- Fraga and Mario González-de la Parra
  
  Moxifloxacin is a synthetic fluoroquinolone with a broad spectrum of antibacterial activity. It is indicated for the treatment of respiratory tract, skin and intra-abdominal infections. The aim of this study was to compare the bioavailability and to determine the bioequivalence of a test and reference formulation of oral moxifloxacin 400 mg, administered as a tablet, and to generate data regarding the oral bioavailability of this drug in Mexican population. This single-dose, randomized-sequence, open-label, two-period, crossover study was conducted on a total of 26 healthy Mexican adult subjects of both genders, with an eight-day washout period. Study formulations were administered after a 10-hour overnight fast. For pharmacokinetic analysis, blood samples were drawn at 0 (baseline), 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, 24, 48 and 72 hours after administration. Plasma concen.. View More»
  DOI: 10.4172/jbb.1000204

  Abstract PDF