Journal of Bioequivalence & Bioavailability

Ahmad F Al-Shunnaq

Publications

• Research Article
  Pharmacokinetics of Gentamicin C after IV, IM, SC and Oral Administration , C , C 1 1a and C 2 in Broiler Chickens 2a
  Author(s): Ehab A Abu-Basha, Ahmad F Al-Shunnaq and Ronette GehringEhab A Abu-Basha, Ahmad F Al-Shunnaq and Ronette Gehring
  
  The pharmacokinetics and bioavailability of four major gentamicin components (C 1 , C 1a , C 2 and C 2a ) in chicken plasma administered at 5 mg/kg body weight by different routes of administration (IV, IM, SC and oral) was determined using reversed-phase high performance liquid chromatography (RP-HPLC) and pre-column derivatization with Phenylisocyanate (PIC). All the components, except for C 1a were well absorbed (bioavailability of 60% or greater) following administration by the IM and SC routes. The bioavailability of C 1a was 58% and 35% following IM and SC administration, respectively. The apparent volume of distribution (V ss and Vd area ) for the C 1 component was significantly smaller than for any of the other components individually or combined. In addition, the C 1 component had a significantly shorter t½β and MRT following intravenous administration and a highe.. View More»
  DOI: 10.4172/jbb.1000147

  Abstract PDF