Journal of Bioequivalence & Bioavailability

Ahmad F Al-Shunnaq

Publications

• Research Article
  Pharmacokinetics and Bioequivalence Comparison of 600 mg Single-Dose Linezolid Oral Suspension and Tablet Formulation in Healthy Chinese Subjects
  Author(s): Ehab A H Abu-Basha, Ronette Gehring, Ahmad F Al-Shunnaq and Saad M GharaibehEhab A H Abu-Basha, Ronette Gehring, Ahmad F Al-Shunnaq and Saad M Gharaibeh
  
  Study background:Linezolid is indicated for the treatment of infections caused by aerobic Gram-positive bacteria. An oral suspension formulation poses an alternative to solid oral formulations in patients with swallowing difficulties, especially pediatric and geriatric patients, or patients with feeding tubes. Methods: This randomized, open-label, two-way cross-over, clinical pharmacology study in healthy Chinese male subjects evaluated the bioequivalence of single-dose 600 mg linezolid oral suspension to single-dose 600 mg linezolid film-coated tablet under fasted conditions. Pharmacokinetic blood sampling was carried out at various time points within 48 h post-dosing and plasma samples were analyzed using a validated high-performance liquid chromatography tandem mass spectrometric method. The primary endpoints were area under plasma concentration– time curve (AUC) from time ze.. View More»
  DOI: 10.4172/jbb.10000197

  Abstract PDF