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Adewole E
Adewole E
Ado Ekiti, Ekiti State
Nigeria
Publications
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Research Article
Characterization and Aldose Reductase Inhibitory Effect of Carica papaya Extract
Author(s): Adewole E Adewole E
Objective and aim: the aim of the research work was to characterize the methanolic extract of C. papaya and then carried out the anti-diabetic inhibitory potential of the extract against Aldose Reductase enzymes. Materials and methodology: The C. papaya leaves were harvested fresh and air dried for five days at room temperature and blended into powdered form using electric blender. It was subsequently subjected to extraction using analytical grade of methanol solvent. Enzymatic reaction assays were performed using standard recommended protocol with slight modifications and the extract was characterized using Gc-Ms. Finally some of the identified compounds were screened for various degrees of drug characteristics using Online OSIRIS property explorer. Results: the IC50 value (1.22 ± 0.63 μg/mL).. View More»
DOI: 10.4172/2153-2435.1000576