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Abdullah M Alnuqaydan
Abdullah M Alnuqaydan
Australia
Publications
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Research Article
Genetic Damage and Cell Killing Induction by Five Head Lice Treatments on HaCaT Human Skin Cells
Author(s): Abdullah M Alnuqaydan and Barbara J Sanderson Abdullah M Alnuqaydan and Barbara J Sanderson
Background: Chemical head lice treatments used by parents to treat head lice infestation in their children due to their rapid and reliable removal of head lice. However, those treatments can be absorbed through the skin. Children are more sensitive to absorbing chemicals than adults. We hypothesized that synthetic chemical-based head lice treatments cause cytotoxic and genotoxic damage to human skin cells in vitro. Objective: To determine the cytotoxic and genotoxic damage of synthetic chemical-based head lice treatments on HaCaT human skin cells in vitro. Methodology: Cytotoxicity measured by the methyl tetrazolium cytotoxicity (MTT) assay and the crystal violet assay. Also, the mechanism of cell killing was identified by the apoptosis detection, via Flow cytometry assay. The cytokinesis block micronucleus (CBMN) assay detected the frequency of binucleated cells (BN) with micronucleu.. View More»
DOI: 10.4172/2157-2518.1000259