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Abdul Bari Mohd
Abdul Bari Mohd
Slovak republic
Publications
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Research Article
Formulation and Pharmacokinetics of Vitamin E TPGS Melt Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen
Author(s): Abdul Bari Mohd and Sateesh Kumar VemulaAbdul Bari Mohd and Sateesh Kumar Vemula
Formulation of solid dispersions using BCS class II drugs is one of the fruitful technologies to improve the drug solubility and dissolution rate to improve the bioavailability, but suffers from poor flowability and stability. To overcome the above problems, present research was intended to prepare the solid dispersions using combination of melt dispersion and surface adsorption methods. In the present study flurbiprofen melt dispersion granules were prepared by incorporating vitamin E TPGS as the carrier material and lactose as an adsorbent to improve the dissolution rate and flowability. Melt dispersion granules were evaluated for angle of repose, solubility studies, differential scanning calorimetry, in vitro dissolution studies, stability studies and finally subjected to pharmacokinetic studies. From the differential scanning calorimetry studies, chang.. View More»
DOI: 10.4172/jbb.1000274