Pharmaceutica Analytica Acta

Abstract

Use of 10% Lipid Emulsion to Reverse Ventricular Fibrillation Following Of an Iatrogenic Local Anesthetic Overdose: A Case Report

Alexandre de Araujo Altamiranda, Raphaella Amanda Maria Leite Fernandes, Ana Maria Menezes Caetano, Fernanda Lobo Lago Flores and Flavia Augusta de Orange

Local anesthetic systemic toxicity (LAST) is a potentially fatal complication. Recognition of its occurrence, appropriate treatment and post-LAST care are essential to ensure a favorable outcome. This report describes the use of a lipid emulsion therapy (10% Lipovenos® emulsion), in a 41-year old woman, who inadvertently received cardioplegia following administration of 0.5% bupivacaine directly into the coronary ostium during extracorporeal circulation for aortic valvuloplasty. Although there have been no reports recommending its use for the pharmacological treatment of LAST to reversed toxicity, 10% lipid emulsion therapy may represent a viable alternative to the use of 20% lipid emulsion.