Pharmaceutica Analytica Acta

Abstract

The Use of Molecularly Imprinted Polymers for Dermal Drug Delivery

Suedee R

Molecular imprinting has played an important role in the fabricating pre-defined drug selectivity in synthesized polymer products, which provides for significant changes in physicochemical property and recognition of its intended application. The physical features of imprinting the cross-linked materials generating a formed shape imprinted cavity have three-dimensional interaction sites contributing to chemical properties are useful for chiral separation of two isomers of asymmetric therapeutically agents through skin crossing biological barriers. The potential methods have created opportunities with advantages of tailor-made specific recognition sites for a given print molecule within an enantioselective molecularly imprinted membrane or nanostructure of engineered devices. Considering recent investigation regarding the in vivo behaviour of various formulation incorporated recognition system and release of desirable enantiomer of chiral therapeutic compounds, which demonstrated enhanced pharmacological effects of systemically administered pharmacologically active enantiomer of the chiral drugs as a result of use of delivery modalities. A number of thus the imprint formulations have been developed to provide for the diffusion of chiral specific molecules the challenges to realize the dream of producing effective biomimetic recognition systems. The review highlights fundamental aspects of chiral recognition processes of a given enantiomer as well as the production of binding site functionality still relies to a crucial extent on selective release of enantiomer of the racemic delivery, then indicate their current use in dermal drug delivery. This review discusses the possible future uses that they contribute advantageous drug delivery. In addition, the potential role of MIPs in studying the effect of physiological function as well as their specific mechanisms is given here.