Global Journal of Biology, Agriculture & Health Sciences

Abstract

THE TOXICITY STUDY OF ETHANOLIC LEAF EXTRACT OF SESAMUM INDICUM ON THE HISTOMORPHOLOGY OF THE LIVER OF ADULT WISTAR RATS

Kelechi C. Uruakpa, Kebe E. Obeten, Eru, M. Eru, & Anozeng O. Igiri

The aim of this work was to assess the toxic effect of ethanolic leaf extract of Sesamum indicum on the histomorphology of the liver of adult Wistar rats. Forty five Wistar rats weighing between 150-180g were divided into three groups of fifteen each (A, B and C). the rats in group A were taken as control and given distilled water, experimental groups B and C received 200mg/kg and 400mg/kg of the leaf extract respectively. The extract was administered for two weeks at the end of which the animals were sacrificed. The kidneys were harvested and processed for H&E staining method. From the results obtained, the administration of ethanol leaf extract of Sesamum indicum caused an ephased architectural pattern with atrophic hepatocytes and dilated sinusoid. This effect is attributed to sesamin content of Sesamum indicum and thus suggest that the extract may be toxic to the liver of Wistar rats.

Published Date: 2013-05-14;